Last updated: August 3, 2020
When progastrin is maturated into gastrin, it is released from the cells.
When gastrin is produced by the G cells of the stomach antrum, it plays its role to control acidic secretions during digestion.
When progastrin is not maturated into gastrin, it is released from the cells as such and named hPG80.
This only happens in tumor cells, whatever the tumor cell: progastrin becomes a circulating protein, hPG80, which can be detected in the blood of cancer patients.
Assessment of hPG80 usability in follow up with surgery.
Patients recorded in prospective BIG-RENAPE project database, NCT02823860 (Lyon, FRANCE). Biological data were extracted from the data base.
Analysis was performed in HCL Lyon Sud facility (Pierre-Bénite, FRANCE).
194 patients with peritoneal involvements from gastrointestinal cancers, treated with peri-operative chemotherapy regimens and cytoreductive surgery.
Blood samples were collected at inclusion (n=194) and between 8 and 24 hours after cytoreductive surgery, performed with or without hyperthermic intraperitoneal chemotherapy (HIPEC) (n=85).
In this cohort, median hPG80 significantly decreased from inclusion to the post-operative period from 3.08 to 1.57 pM[AP1] , p<0.0001 with two-tailed unpaired Mann-Whitney test.
The individual curves showed that 74.2% of patients had hPG80 titer declines >25%. The remaining patients experienced stable concentrations (16.1% of patients), or hPG80 level increases >25% (9.7% of patients).
hPG80 is a good biomarker for peritoneal carcinomatosis patients to assess surgery efficacy.
Levels are significantly decreased after surgery and individual follow-up shows that minimal residual disease might be questioned via the presence of hPG80 in the blood.
These results have been published in You et al, EBioMedicine, 2020.
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